Independent research.
Evidence first.
Smith Genetic Research is an independent initiative focused on investigating biological questions related to opioid exposure. We examine the science, evaluate the evidence, and work to advance understanding for a healthier tomorrow.
Independent Research
We pursue questions through
independent, unbiased research.
Evidence Review
We analyze and synthesize
the best available evidence.
Public Understanding
We make complex science
clear and accessible.
Future Inquiry
We identify new questions to
inform ongoing research.
Advancing understanding
through independent research.
Smith Genetic Research investigates whether opioid exposure may be associated with measurable changes in human biology. Our work combines genetic and epigenetic research, evidence review, and transparent communication to help inform science, policy, and public understanding.
Learn About Our Approach →
Douglas R. Smith, MD
Physician. Researcher. Author.
Dr. Douglas R. Smith is a physician, independent researcher, and author of The Opioid Question. He founded Smith Genetic Research to explore unanswered questions related to opioid exposure, with a focus on genetic and epigenetic research.
His work is driven by a commitment to evidence, transparency, and informed discussion — and a belief that science can help lead to better answers for individuals, families, and future generations.
Learn More About Dr. Smith →“A clear, thoughtful and evidence-based look at one of the most important health questions of our time.”
— Readers
From clinical experience
to independent research.
A continuing journey to better understand the long-term biological effects of opioid exposure through science, evidence, and open dialogue.
Early Career
Years of clinical practice and firsthand experience with the impact of opioids on patients and families.
2010–2015
Began exploring genetic and epigenetic research related to environmental exposures.
2016
Founded Smith Genetic Research to pursue independent investigation of the opioid question.
2018+
Expanded research, published findings, and engaged with the scientific and regulatory community.
Today
Continuing to investigate, share evidence, and advance public understanding.
Scientific Inquiry
We pursue evidence
and ask better questions.
Integrity
We are committed to
honesty, rigor, and
intellectual independence.
Independence
We operate independently
of commercial and
political interests.
Collaboration
We engage with researchers,
clinicians, and stakeholders
to advance understanding.
Education
We make science
accessible and meaningful
to more people.
Public Impact
We strive to inform
decisions that support
a healthier tomorrow.
Evidence-Led
We ground our work in peer-reviewed research, regulatory records, and high-quality scientific sources — not speculation.
Independent
We are not funded by pharmaceutical companies or special interest groups, allowing us to ask difficult questions and follow the evidence.
Question-Driven
We remain focused on the unanswered questions about opioid exposure and its potential long-term effects on human biology.
The Opioid Question
Dr. Douglas R. Smith takes you inside the science, the questions, and the human stories behind opioid exposure. This book explores the evidence, the unanswered questions, and the path toward a healthier tomorrow.
An important contribution to a more informed conversation about opioids and human health.
Readers