Resources
The articles, analyses and data behind the research questions are collected here for review.
Research Articles
Buprenorphine for the stabilization of the primary neurotoxicity secondary to opioid genotoxicity
An examination of the potential for buprenorphine to stabilize neurotoxic effects that may result from opioid related genetic damage, and its implications for long-term health.
March 15, 2024
Part 2: Two separate and distinct populations
An analysis suggesting the existence of two separate and distinct populations within opioid exposed individuals, with different genetic and epigenetic profiles.
April 22, 2024
Part 3: Naming the genotoxicity and the 133,805 patient day datapoints
A deeper examination of the potential genotoxic effects of opioid exposure, including analysis of 133,805 patient day datapoints and what they may indicate.
June 10, 2024
Data and Charts
Estimated cardiovascular deaths due to opioid withdrawal through 2019
This chart shows estimated cardiovascular deaths associated with opioid withdrawal from 2010 through 2019. It is an estimate based on available data and does not establish causation.
Source: Smith Genetic Research analysis of publicly available data, 2024.
Projected cardiovascular deaths due to opioid withdrawal through 2024
This chart shows projected cardiovascular deaths associated with opioid withdrawal from 2020 through 2024. It is a projection based on current trends and does not establish causation.
Source: Smith Genetic Research analysis of publicly available data, 2024.
Regulatory Documents
Citizens Petition 1
Request for regulatory review related to opioid exposure and potential genetic and epigenetic effects.
View documentCitizens Petition 2
Additional research questions related to opioid exposure and biological markers in human DNA.
View documentHow to Read This Library
The resources in this library include published research, our own analyses, regulatory documents and background material. The evidence levels below indicate how each item should be viewed.
Findings from peer reviewed studies and established sources.
Our analysis and interpretation of existing evidence.
Questions we are exploring that require further study.
Areas where additional data collection is needed.
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